江　鹏-凯发k8

副教授

1999-2003年 安徽大学生物技术系 学士

2003-2008年 中国科学技术大学分子细胞生物学系 博士

2008-2013年 美国宾夕法尼亚大学医学院 博士后
2013-2014年 美国宾夕法尼亚大学医学院 research associate

2014-2021年 清华大学生命科学学院 助理教授

2021-         清华大学生命科学学院 副教授

2020-         清华-北大生命科学联合中心，pi

●  研究兴趣、领域：

肿瘤和免疫代谢。实验室主要研究肿瘤和免疫细胞中代谢异常发生的调控机制，以及细胞感知微环境中代谢物质改变的分子机制和生理、病理功能。

 

●  代表性论文：

1. xu x, wang j, xu l, li p*, jiang p*. p53 suppresses lipid droplet-fueled tumorigenesis through phosphatidylcholine. j clin invest. 2024 jan 9;134(4).

2. chen t#, xie s#, cheng j, zhao q, wu h*, jiang p*, du w*. akt1 phosphorylation of cytoplasmic me2 induces a metabolic switch to glycolysis for tumorigenesis. nat communs. (2024) jan 23;15(1):686.

3. xia w, jiang p*. p53 promotes antiviral innate immunity by driving hexosamine metabolism. cell reports. (2024) jan 30;43(2):113724.

4. cheng j#, yan j#, liu y#, shi j#, wang h, zhou h, zhou y, zhang t, zhao l, meng x, gong h, zhang x*, zhu h*, jiang p*. cancer-cell-derived fumarate suppresses the anti-tumor capacity of cd8 t cells in the tumor microenvironment. cell metabolism. (2023) jun 6;35(6):961-978.

5. cheng, j#, liu, y#, yan, j#, zhao l, zhou y, shen x, y, chen y, meng x, zhang x* & jiang p*. fumarate suppresses b-cell activation and function through direct inactivation of lyn. nature chemical biology (2022). sep;18(9):954-962.

6. zhao m#, yao p#, mao y#, wu j#, wang w, geng c, cheng j, du w * and jiang p*. malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. nature metabolism. (2022). feb;4(2):225-238.

7. mao y, shi d, li g, jiang p*. citrulline depletion by ass1 is required for proinflammatory macrophage activation and immune responses. molecular cell. (2022) feb 3;82(3):527-541.

8. li g#, wu j#, li l, jiang p*. p53 deficiency induces mthfd2 transcription to promote cell proliferation and restrain dna damage. proc natl acad sci u s a. (2021) jul 13;118(28)

9. wu j#, li g#, li l, li d, dong z, jiang p*. asparagine enhances lck signalling to potentiate cd8 t cell-activation and anti-tumour responses. nature cell biology, (2021) 23(1):75-86.

10. deng l, yao p, li l, ji f, zhao s, xu c, lan x, jiang p*. p53-mediated control of aspartate-asparagine homeostasis dictates lkb1 activity and modulates cell survival. nature communs, (2020) 11, 1755-18;

11. li l, mao y, zhao l, li l, wu j, zhao m, du w, yu l, jiang p*. p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis. nature. (2019) 567(7747):253-256.

12. li l#, li l#, li w, chen t, bin zou, zhao l, wang h, wang x, xu l, liu x, wang d, li b, mak tw, du w*, yang x*, jiang p*. tap73-induced phosphofructokinase-1 transcription promotes the warburg effect and enhances cell proliferation. nature communs. (2018), nov 8; 9(1):4683.

13. du w#, jiang p#, mancuso a, stonestrom a, brewer m, minn aj, mak tw, wu m* and yang x*. tap73 enhances the pentose phosphate pathway and supports cell proliferation. nature cell biology. (2013), aug. 15, 991–1000.

14. jiang p#, du w#, mancuso a, wellen ke, yang x*. reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. nature. (2013), jan. 493: 689-693.

15. jiang p#, du w#, wang x, mancuso a, gao x, wu m* and yang x*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. nature cell biology. (2011) mar.13: 310-316.

●  凯发k8的联系方式：

email: jiang-lab@mail.tsinghua.edu.cn
phone:010-62786079 (office), or 010-62783063 (laboratory)