罗永章-凯发k8

教授

1981-1985 兰州大学化学系物理化学专业                                      学士                             

1989-1993 美国加州大学伯克利分校分子与细胞生物学系生物化学专业      博士      

1993-1994 美国哈佛大学医学院生物化学与分子药物学系                  博士后      

1994-1998 美国斯坦福大学医学院生物化学系                               博士后     

现任清华大学教授

●  研究兴趣、领域：

课题组基于国家一类重组蛋白质候选药物，从全新角度探索疾病的分子机理并寻找潜在的治疗手段，研究兴趣如下：

    1) 2型糖尿病、肥胖等代谢疾病

    2) 阿尔茨海默症、帕金森症等退行性疾病

●  代表性论文：

1. ma b, ju a, zhang s, an q, xu s, liu j, yu l, fu y & luo y*. albumosomes formed by pre-folding albumin in cytoplasm of hepatocytes maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.

signal transduct target ther. 2023;8(1):229.doi: 10.1038/s41392-023-01437-0.

2. liu, h., ju, a., dong, x. et al. young and undamaged recombinant albumin alleviates t2dm by improving hepatic glycolysis through egfr and protecting islet β cells in mice. j transl med 21, 89 (2023). https://doi.org/10.1186/s12967-023-03957-3

3. tang j, ju a, li b, et al. young and undamaged rmsa improves the healthspan and lifespan of mice. biomolecules. 2021;11(8):1191. doi:10.3390/biom11081191

4. liu w, li j, zhang p, et al. a novel pan-cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic. cancer sci. 2019;110(9):2941-2959. doi:10.1111/cas.14143

5. fu y, xu x, huang d, et al. plasma heat shock protein 90alpha as a biomarker for the diagnosis of liver cancer: an official, large-scale, and multicenter clinical trial. ebiomedicine. 2017;24:56-63. doi:10.1016/j.ebiom.2017.09.007

6. wang h, chen y, lu xa, liu g, fu y, luo y. endostatin prevents dietary-induced obesity by inhibiting adipogenesis and angiogenesis. diabetes. 2015;64(7):2442-2456. doi:10.2337/db14-0528

7. wang x, song x, zhuo w, et al. the regulatory mechanism of hsp90alpha secretion and its function in tumor malignancy. proc natl acad sci u s a. 2009;106(50):21288-21293. doi:10.1073/pnas.0908151106

8. huang y, song n, ding y, et al. pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis. cancer res. 2009;69(19):7529-7537. doi:10.1158/0008-5472.can-08-4382. “this landmark study demonstrated that angpt2-, mmp3- and mmp10-dependent pulmonary vascular destabilization is an early event occurring during the pre-metastatic phase, which promotes the extravasation of tumour cells and facilitates lung metastasis.” cited and commented by peinado, h., zhang, h., matei, i. et al. pre-metastatic niches: organ-specific homes for metastases. nat rev cancer 17, 302–317 (2017). https://doi.org/10.1038/nrc.2017.6

9. shi h, huang y, zhou h, et al. nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin. blood. (featured in cover) 2007;110(8):2899-2906. doi:10.1182/blood-2007-01-064428 comment on shi et al, page 2899, by judah folkman (2007). “endostatin finds a new partner: nucleolin” blood. 110, 2786-2787

●  凯发k8的联系方式：

电话： 86-10-62795106

传真： 86-10-62794691

e-mail: protein@tsinghua.edu.cn