王一国-凯发k8

副教授

1997.9－2001.7       曲阜师范大学生命科学学院 学士

2001.9－2007.1       中科院上海生物化学与细胞生物学研究所     博士

2007.8－2012.8       美国索儿克研究所   博士后

2012.8－                  清华大学生命科学学院  副教授

●  研究兴趣、领域：

糖脂代谢稳态的激素信号调控：

1. 高等生物特有新激素的发现；

2. 新激素对糖脂代谢稳态的调控；

3. 新激素在代谢性疾病中的作用。

●  代表性论文：

1. xiaoli hu^#, fengyi chen^#, liangjie jia, aijun long, ying peng, xu li, junfeng huang, xueyun wei, xinlei fang, zihua gao, mengxian zhang, xiao liu, ye-guang chen, yan wang, huijie zhang*, yiguo wang*. (2024) a gut-derived hormone regulates cholesterol metabolism. cell 187, 1685-1700.

2. aijun long^#, yang liu^#, xinlei fang, liangjie jia, zhiyuan li, jiang hu, shuang wu, chao chen, ping huang* and yiguo wang*. (2023) famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor olfr796. cell res. 33, 273-287. (cover article)

3. yi liu^#, yuanyuan zhang^#, tong li, jinbo han and yiguo wang*. (2020) the tight-junction protein tjp1 regulates the feeding-modulated hepatic circadian clock. nat commun. 11(1), 589.

4. erwei li^#, haili shan^#, liqun chen^#, aijun long^#, yuanyuan zhang^#, yang liu, liangjie jia, fangchao wei, jinbo han, tong li, xiaohui liu, haiteng deng and yiguo wang*. (2019) olfr734 mediates glucose metabolism as a receptor of asprosin. cell metab. 30, 319-328.

5. liqun chen^#, ke wang^#, aijun long, liangjie jia, yuanyuan zhang, haiteng deng, yu li, jinbo han and yiguo wang*. (2017) fasting-induced hormonal regulation of lysosomal function. cell res. 27, 748-763.

6. jinbo han^#, erwei li^#, liqun chen, yuanyuan zhang, fangchao wei, jieyuan liu, haiteng deng and yiguo wang*. (2015). the creb coactivator crtc2 controls hepatic lipid metabolism by regulating srebp1. nature 524, 243-246.

7. yiguo wang, gang li, jason goode, jose c. paz, kunfu ouyang, robert screaton, wolfgang h. fischer, ju chen, ira tabas and marc montminy*. (2012). insp3 receptor regulates hepatic gluconeogenesis in fasting and diabetes. nature 485, 128-132.

8. yiguo wang, hiroshi inoue, kim ravnskjaer, kristin viste, nina miller, yi liu, susan hedrick, liliana vera, and marc montminy*. (2010). targeted disruption of the creb coactivator crtc2 increases insulin sensitivity. proc natl acad sci u s a. 107, 3087-3092.

9. yiguo wang, liliana vera, wolfgang h fischer, marc montminy*. (2009). the creb coactivator crtc2 links hepatic er stress and fasting gluconeogenesis. nature 460, 534-537.

10. yiguo wang, dan du, longhou fang, guang yang, chenyi zhang, rong zeng, axel ullrich, friedrich lottspeich, zhengjun chen*.  tyrosine phosphorylated par3 regulates epithelial tight junction assembly promoted by egfr signaling.  the embo journal. (2006) 25, 5058-5070.

●  凯发k8的联系方式：

电话： 86-10-62783209

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