教授 中国科学院院士 美国科学院外籍院士 美国艺术与科学院外籍院士
1985-1989 |
清华大学生物科学与技术系，学士 |
1990-1995 |
美国约翰霍普金斯大学医学院，分子生物物理学博士 |
1995 |
美国约翰霍普金斯大学医学院，博士后 |
1996-1997 |
美国纽约斯隆•凯特林癌症研究中心，博士后 |
1998-2001 |
美国普林斯顿大学分子生物学系，助理教授 |
2001-2003 |
美国普林斯顿大学分子生物学系，（终身）副教授 |
2003-2007 |
美国普林斯顿大学分子生物学系，（终身）教授 |
2007-2008 |
美国普林斯顿大学分子生物学系，warner-lambert/parke-davis教授 |
2008-至今 |
清华大学生命科学学院，教授、博导 |
● 研究兴趣、领域：
主要运用结构生物学、生物化学和生物物理的手段研究rna剪接、细胞凋亡等细胞内生物大分子机器的结构与功能，以及γ-分泌酶介导的阿尔茨海默症的分子机制。
● 代表性论文 (# indicates corresponding authors)：
1. guanghui yang, rui zhou, xuefei guo, chuangye yan, jianlin lei, yigong shi# (2021). structural basis of γ-secretase inhibition and modulation by small molecule drugs. cell, 184(2):521-533.
2. gaoxingyu huang, yanqing zhang, xuechen zhu, chao zeng, qifan wang, qiang zhou, qinghua tao, minhao liu, jianlin lei, chuangye yan and yigong shi# (2020). structure of the cytoplasmic ring of the xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis. cell research, 30(6):520–531.
3. rui zhou, guanghui yang, xuefei guo, qiang zhou, jianlin lei, yigong shi# (2019). recognition of the amyloid precursor protein by human γ-secretase. science, 363(6428):eaaw0930.
4. guanghui yang, rui zhou, qiang zhou, xuefei guo, chuangye yan, meng ke, jianlin lei & yigong shi# (2019). structural basis of notch recognition by human γ-secretase. nature, 565(7738):192-197.
5. rui bai, ruixue wan, chuangye yan, jianlin lei, yigong shi# (2018). structures of the fully assembled saccharomyces cerevisiae spliceosome before activation. science, 360(6396):1423-1429.
6. xiechao zhan, chuangye yan#, xiaofeng zhang, jianlin lei, yigong shi# (2018). structure of a human catalytic step i spliceosome. science, 359(6375): 537-545.
7. xiaofeng zhang, chuangye yan#, jing hang, lorenzo i. finci, jianlin lei, and yigong shi# (2017). an atomic structure of the human spliceosome. cell, 169(5):918-929.
8. rui bai, chuangye yan, ruixue wan, jianlin lei, and yigong shi# (2017). structure of the post-catalytic spliceosome from saccharomyces cerevisiae. cell, 171(7):1589-1598.
9. chuangye yan, ruixue wan, rui bai, gaoxingyu huang, yigong shi# (2016). structure of a yeast catalytically activated spliceosome at 3.5 å resolution. science, 353(6302):904-911.
10. ruixue wan, chuangye yan, rui bai, gaoxingyu huang, yigong shi# (2016). structure of a yeast catalytic step i spliceosome at 3.4 å resolution. science, 353(6302):895-904.
11. chuangye yan, jing hang, ruixue wan, min huang, catherine c. l. wong, yigong shi# (2015). structure of a yeast spliceosome at 3.6-angstrom resolution. science, 349(6253):1182-1191.
12. jing hang, ruixue wan, chuangye yan, and yigong shi# (2015). structural basis of pre-mrna splicing. science, 349(6253):1191-1198.
13. mengying zhou, yini li, qi hu, xiaochen bai, weijiao huang, chuangye yan, sjors h. w. scheres#, and yigong shi# (2015). atomic structure of the apoptosome: mechanism of cytochrome c- and datp-mediated activation of apaf-1. genes & development, 29(22):2349-2361.
14. peilong lu, xiao-chen bai, dan ma, tian xie, chuangye yan, linfeng sun, guanghui yang, yanyu zhao, rui zhou, sjors h. w. scheres# & yigong shi# (2014). three-dimensional structure of human γ-secretase. nature, 512(7513): 166-170.
15. shiqian qi, yuxuan pang, qi hu, qun liu, hua li, yulian zhou, tianxi he, qionglin liang, yexing liu, xiaoqiu yuan, guoan luo, huilin li, jiawei wang, nieng yan#, and yigong shi# (2010). crystal structure of the caenorhabditis elegans apoptosome reveals an octameric assembly of ced-4. cell, 141(3):446-457.
● 凯发k8的联系方式：
电话： 86-10-62797560(实验室)
e-mail: shi-lab@mail.tsinghua.edu.cn
web: https://ygshi.org
