senfang sui-凯发k8

professor, member of chinese academy of sciences

1964-1970   b. s., department of precision instrument, tsinghua university.

1978-1981   m.s., department of engineering physics, tsinghua university.

1985-1988   ph.d., biophysics institute, technical university munich.

1989-1991   associate professor, department of biological sciences and biotechnology, tsinghua university.

1991.01-present     professor, school of life sciences (replacing the department of biological sciences and biotechnology in september of 2009 ), tsinghua university.

research interest

using cryo-electron microscopy (cryo-em) in combination with biochemical, biophysical and cellular methods, our lab currently focuses on: (1) structures, functions and mechanisms of large protein complexes, macromolecular machines and membrane proteins, and (2) molecular mechanisms of membrane trafficking, lipid-protein interactions and membrane-related human diseases.

representative publications

1. li zq, chen s, zhao l, huang gq, xu h, yang xy, wang py, gao n, sui sf*. (2023) nuclear export of pre-60s particles through the nuclear pore complex. nature, 618(7964):411-418.

2. you x, zhang x, cheng j, xiao yn, ma jf, sun s, zhang xz*, wang hw*, sui sf*. (2023) in situ structure of the red algal phycobilisome–psii–psi–lhc megacomplex. nature, 616(7955):199-206.

3. sun s*, sui sf. (2023) structural insights into assembly of trappii and its activation of rab11/ypt32. curr opin struct biol., 80:102596. (review)

4. li zq, chen s, zhao l , huang gq, pi x , sun s, wang py, sui sf*. (2022) near-atomic structure of the inner ring of the saccharomyces cerevisiae nuclear pore complex. cell research, 32(5):437-450.

5. mi cc, zhang l, huang gq, shao g, yang f, you x, dong mq, sun s*, sui sf*. (2022) structural basis for assembly of trappii complex and specific activation of gtpase ypt31/32. science advances, 8(4):eabi5603.

6. xiao yn, huang gq, you x, zhu q, wang w, kuang ty, han h*, sui sf*, shen jr*. (2021) structural insights into cyanobacterial photosystem ii intermediates associated with psb28 and tsl0063. nat plants, 7(8):1132-1142.

7. sui sf*. (2021) structure of phycobilisomes. annu rev biophys., 50:53-72.

8. hu mq, yang f, huang yw, you x, liu d, sun s*, sui sf*. (2021) structural insights into the mechanism of human npc1l1-mediated cholesterol uptake. science advances, 7(29):eabg3188.

9. ma j, you x, sun s, wang x, qin s, sui sf*. (2020) structural basis of energy transfer in porphyridium purpureum phycobilisome. nature, 579(7797):146-151.

10. pi x, zhao s, wang w, liu d, xu c, han g, kuang t*, sui sf*, shen jr*. (2019) the pigment-protein network of a diatom photosystem ii-light-harvesting antenna supercomplex. science, 365(6452):eaax4406.

11. huang x, sun s, wang x, fan f, zhou q, lu s, cao y, wang qw, dong mq, yao j, sui sf*. (2019) mechanistic insights into the snare complex disassembly. science advances, 5(4):eaau8164.

12. qin x, pi x, wang w, han g, zhu l, liu m, cheng l, shen jr, kuang t*, sui sf*. (2019) structure of a green algal photosystem i in complex with a large number of light-harvesting complex i subunits. nat plants, 5(3):263-272.

13. pi x, tian l, dai he, qin x, cheng l, kuang t, sui sf*, shen jr*. (2018) unique organization of photosystem i-light-harvesting supercomplex revealed by cryo-em from a red alga. proc natl acad sci usa, 115(17):4423-4428.

14. zhang j, ma j, liu d, qin s, sun s*, zhao j, sui sf*. (2017) structure of phycobilisome from the red alga griffithsia pacifica. nature, 551(7678):57-63.

15. hu z, zhou q, zhang c, fan s, cheng w, zhao y, shao f, wang hw, sui sf*, chai j*. (2015) structural and biochemical basis for induced self-propagation of nlrc4. science, 350(6259):399-404.

contact information

tel: 86-10-62792083/62784768
e-mail: suisf@mail.tsinghua.edu.cn
lab website: http://suilab.life.tsinghua.edu.cn/