zhi lu-凯发k8

associate professor

2017-present bioinformatics and genomics associate professor tsinghua university, beijing, china
2011-2016 bioinformatics and genomics assistant professor tsinghua university, beijing, china
2008-2011 bioinformatics postdoc yale university, new haven, ct, us
2003-2008 biophysics ph.d. university of rochester, rochester, ny, us
1998-2003 life sciences b.s. university of science and technology of china

research interest

our group is interested in developing bioinformatics technologies, and practicing evidence-based precision medicine for diseases like cancer. we utilize machine learning and ai technologies, together with noncoding rna (ncrna) centered multi-omics data, to understand how genetic information is encoded in the structured dna and rna sequences, and how they interact and regulate each other in a biological system. ultimately, this will help us understand and cure human diseases, know and improve ourselves.

we have two major research directions based on noncoding rna (ncrna):

i. bioinformatics-driven precision medicine;

ii. ai-driven rna target prediction and drug design.

selected publications

· mingyang li¹, tianxiu zhou¹, mingfei han¹, hongke wang, pengfei bao, yuhuan tao, xiaoqing chen, guansheng wu, tianyou liu, xiaojuan wang, qian lu*, yunping zhu*, zhi john lu* (2024) cfomics: a cell-free multi-omics database for diseases. nucleic acids research 52(d1):d607-d621 (1contributed equally, *co-corresponding authors)

· yuhuan tao¹, shaozhen xing¹, shuai zuo¹, pengfei bao, yunfan jin, yu li, yingchao wu, shanwen chen, xiaojuan wang, yumin zhu, ying feng, xiaohua zhang, xianbo wang, qiaoran xi, qian lu*, pengyuan wang*, zhi john lu* (2023) cell-free multi-omics analysis reveals potential biomarkers in gastrointestinal cancer patients’ blood. cell reports medicine 4(11):101281 (1contributed equally, *co-corresponding authors)

· shanwen chen¹, yunfan jin, siqi wang¹, shaozhen xing¹, …, zhenjiang zech xu*, zhi john lu*, pengyuan wang* (2022) cancer type classification using plasma cell free rnas derived from human and microbes. elife 11:e75181 (1contributed equally, *co-corresponding authors)

· weihao zhao¹, shang zhang¹, …, yucheng t yang*, zhi john lu* (2022) postar3: an updated platform for exploring post-transcriptional regulation coordinated by rna-binding proteins. nucleic acids research 50(d1):d287-d294

· shuaishuai teng¹, yang eric li¹, …, zhi john lu* and dong wang* (2020) tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer. cell research 30(1):34-49

· zhiyu xu¹, long hu¹, …, dong wang* & zhi john lu* (2018) ribosome elongating footprints denoised by wavelet transform comprehensively characterize dynamic cellular translation events. nucleic acids research 46 (18), e109-e109

· jiapei yuan¹, jingrui li¹, …, yijun qi* & zhi john lu* (2018) stress-responsive regulation of long noncoding rnas’ polyadenylation in oryza sativa. the plant journal (1contributed equally) 93:5, 814-827

· encode project consortium#. (2012) an integrated encyclopedia of dna elements in the human genome. nature 489, 57–74. (#lu z was a member of encode consortium) [cover story] （cited  ~20,000）

· gerstein mb ¹*, lu zj¹, van nostrand el¹, cheng c¹, arshinoff bi¹, et al. (2010) integrative analysis of the caenorhabditis elegans genome by the modencode project. science 330(6012): 1775-1787 (20 co-first authors, *15 co-corresponding authors, ~150 authors in total) [cover story]

contact information

tel. /fax: 86-10-62789217
e-mail: lulab1 at tsinghua.edu.cn
lab page: |

moe key lab of bioinformatics, school of life sciences, tsinghua university, beijing 100084, china