guoqiang chen-凯发k8
professor
1981-1985 bsc, south china university of technology, guangzhou, china
1986-1989 phd, graz university of technology, graz, austria
1990-1992 postdoc., university of nottingham, uk
1992-1994 postdoc., university of alberta, canada
1994-1997 associate professor, tsinghua university
1997-present professor, tsinghua university
research interest
synthetic biology; microbial metabolic engineering; biological materials; industrial biotechnology
selected publications
1） huan wang; jian-wen ye; xinyu chen; yiping yuan; jingwen shi; xinyi liu; fang yang; yueyuan ma; jinchun chen; fuqing wu; yuxuan lan; qiong wu; yi tong; guo-qiang chen ; production of pha copolymers consisting of 3-hydroxybutyrate and 3-hydroxyhexanoate (phbhhx) by recombinant halomonas bluephagenesis, chemical engineering journal, 2023, 466(143261)
2） li, mengyi; ma, yueyuan; zhang, xu; zhang, lizhan; chen, xinyu; ye, jian-wen; chen, guo-qiang; tailor-made polyhydroxyalkanoates by reconstructing pseudomonas entomophila, advanced materials, 2021, 33(41)
3） xiao-ran jiang; xu yan; lin-ping yu; xin-yi liu; guo-qiang chen ; hyperproduction of 3-hydroxypropionate by halomonas bluephagenesis, nature communications, 2021, 12(1)
4） shu-jie zhang; zi-hua li; yu-dian zhang; jin chen; yuan li; fu-qing wu; wei wang; zong jie cui; guo-qiang chen ; ketone body 3-hydroxybutyrate ameliorates atherosclerosisvia receptor gpr109a-mediated calcium influx, advanced science, 2021, 2021(2003410)
5） hong ma; yiqing zhao; wuzhe huang; lizhan zhang; fuqing wu; jianwen ye; guo-qiang chen ; rational flux-tuning of halomonas bluephagenesis for co-production of bioplastic phb and ectoine, nature communications, 2020, 11(1): 3313
6） jian-wen ye; yi-na lin; xue-qing yi; zhuo-xuan yu; xu liu; guo-qiang chen ; synthetic biology of extremophiles: a new wave of biomanufacturing, trends in biotechnology, 2023, 41(3): 342-357
7） mengke ji; taoran zheng; ziyu wang; weijian lai; lizhan zhang; qianyi zhang; hongyi yang; si meng; wanghui xu; cuihuan zhao; qiong wu; guo-qiang chen ; phb production from food waste hydrolysates by halomonas bluephagenesis harboring phb operon linked with an essential gene, metabolic engineering, 2023, 77: 12-20
8） yudian zhang; zihua li; xinyi liu; xinyu chen; shujie zhang; yuemeng chen; jiangnan chen; jin chen; fuqing wu; guo-qiang chen ; 3-hydroxybutyrate ameliorates insulin resistance by inhibiting pparγ ser273 phosphorylation in type 2 diabetic mice, signal transduction and targeted therapy, 2023, 8(1)
9） yueyuan ma; xiangrui zheng; yina lin; lizhan zhang; yiping yuan; huan wang; james winterburn; fuqing wu; qiong wu; jian-wen ye; guo-qiang chen ; engineering an oleic acid-induced system for halomonas, e. coli and pseudomonas, metabolic engineering, 2022, 72: 325-336
10） fanfan chen; xinyi liu; xiyuan ge; yong wang; zifan zhao; xu zhang; guo-qiang chen; yuchun sun ; porous polydroxyalkanoates (pha) scaffolds with antibacterial property for oral soft tissue regeneration, chemical engineering journal, 2022, 451(138899)
11） xuan wang; jia-ning han; xu zhang; yue-yuan ma; yi-na lin; huan wang; dian-jie li; tao-ran zheng; fu-qing wu; jian-wen ye; guo-qiang chen ; reversible thermal regulation for bifunctional dynamic control of gene expression in escherichia coli, nature communications, 2021, 12(1411): 1411
12） wang, ziyu; qin, qin; zheng, yifei; li, fajin; zhao, yiqing; chen, guo-qiang ; engineering the permeability of halomonas bluephagenesis enhanced its chassis properties, metabolic engineering, 2021, 67: 53-66
13） lin-ping yu; xu yan; xu zhang; xiangbin chen; qiong wu; xiao-ran jiang; guo-qiang chen ; biosynthesis of functional polyhydroxyalkanoates by engineered halomonas bluephagenesis, metabolic engineering, 2020, 59: 119-130
14） ye jianwen; hu dingkai; yin jin; huang wuzhe; xiang ruijuan; zhang lizhan; wang xuan; han jianing; chen guo-qiang ; stimulus response-based fine-tuning of polyhydroxyalkanoate pathway in halomonas, metabolic engineering, 2019, 57: 85-95
15） yong chen; xin-yu chen; he-tong du; xu zhang; yi-ming ma; jin-chun chen; jian-wen ye; xiao-ran jiang; guo-qiang chen ; chromosome engineering of the tca cycle in halomonas bluephagenesis for production of copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (phbv), metabolic engineering, 2019, 54: 82
awards
2023 international metabolic engineering award
2022 natural resources science and technology award - science and technology progress award
2021 key technology for production of high quality pla and pha together with related detivated products
2012 “basic research on application of polyhydroxyalkanoates as a tissue engineering material” silver medal of scientific achievement awarded by beijing minicipal government
2002 national invention silver medal award (chinese ministry of sci and technol)
contact information
tel：010－62783844 (office)
email：chengq@tsinghua.edu.cn
